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Dr Patsy Soon

Clinical Academic

The aim of the Breast Cancer Group is to identify novel biomarkers and therapeutic targets in breast cancer patients. The current major projects within the group involves studying and identifying treatment targets against the supporting cells of the breast cancer, known as cancer-associated fibroblasts, as these cells are known to increase the aggressiveness of the cancer cells. Circulating tumour cells, which are cancer cells within the blood of breast cancer patients, are also being studied as a non-invasive indicator of the amount of cancer within the patient.

Publications

C1 - Journal Article

  • Shah JS; Gard GB; Yang J; Maidens J; Valmadre S; Soon PS; Marsh DJ 2017, Combining serum microRNA and CA-125 as prognostic indicators of preoperative surgical outcome in women with high-grade serous ovarian cancer, Gynecologic Oncology
  • Zheng S; Cherniack AD; Dewal N; Moffitt RA; Danilova L; Murray BA; Lerario AM; Else T; Knijnenburg TA; Ciriello G 2016, Comprehensive pan-genomic characterization of adrenocortical carcinoma, Cancer Cell
  • Shah JS; Soon PS; Marsh DJ 2016, Comparison of methodologies to detect low levels of hemolysis in serum for accurate assessment of serum microRNAs, PloS One
  • Selvendran S, Cheluvappa R, Trương VK, Yarrow S, Pang TC, Segara D, Soon P 2016, "Efficacy of harmonic focus scalpel in seroma prevention after axillary clearance", International Journal of Surgery
  • Ip JCY, Pang TCY, Pon CK, Zhao JT, Sywak MS, Gill AJ, Soon PS, Sidhu SB 2015, "Mutations in KCNJ5 determines presentation and likelihood of cure in primary hyperaldosteronism", ANZ Journal of Surgery, vol. 85, no. 4, pp. 279-283
  • Glover AR, Zhao JT, Gill AJ, Weiss J, Mugridge N, Kim E, Feeney AL, Ip JC, Reid G, Clarke S, Soon PSH, Robinson BG, Brahmbhatt H, MacDiarmid JA, Sidhu SB 2015, "microRNA-7 as a tumor suppressor and novel therapeutic for adrenocortical carcinoma", Oncotarget, vol. 6, no. 34, pp. 36675-36688
  • Ip JCY, Pang TY, Glover A, Soon P, Zhao J, Clarke S, Robinson BG, Gill AJ, Sidhu SB 2015, "Immunohistochemical validation of overexpressed genes identified by global expression microarrays in adrenocortical carcinoma reveals potential predictive and prognostic biomarkers", The Oncologist, vol. 20, no. 3, pp. 247-256
  • Glover AR, Zhao JT, Ip JC, Lee JC, Robinson BG, Gill AJ, Soon PSH, Sidhu SB 2015, "Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence", Endocrine-Related Cancer, vol. 22, no. 1, pp. 99-109
  • Ip JC, Pang TC, Glover AR, Soon P, Clarke S, Richardson A, Campbell P, Robinson BG, Sidhu SB 2014, "Improving Outcomes in Adrenocortical Cancer: An Australian Perspective", Annals of Surgical Oncology
  • Zearo S, Kim E, Zhu Y, Zhao JT, Sidhu SB, Robinson BG, Soon PSH 2014, "MicroRNA-484 is more highly expressed in serum of early breast cancer patients compared to healthy volunteers", BMC Cancer, vol. 14, no. 1
  • Soon P; Kiaris H 2013, MicroRNAs in the tumour microenvironment: Big role for small players, Endocrine-Related Cancer
  • Glover AR; Ip JCY; Zhao JT; Soon PSH; Robinson BG; Sidhu SB 2013, Current management options for recurrent adrenocortical carcinoma, OncoTargets and Therapy, Dovepress
  • Soon PSH; Kim E; Pon CK; Gill AJ; Moore K; Spillane AJ; Benn DE; Baxter RC 2013, Breast cancer-associated fibroblasts induce epithelial-to-mesenchymal transition in breast cancer cells, Endocrine - Related Cancer, Society Endocrinology
  • Akerstrom T; Crona J; Delgado verdugo A; Starker LF; Cupisti K; Knoefel WT; Soon PSH 2012, Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter, PloS One, Public Library Science
  • Singh P; Soon PSH; Feige JJ; Chabre O; Zhao JT; Cherradi N; Lalli E; Sidhu SB 2012, Dysregulation of microRNAs in adrenocortical tumors, Molecular And Cellular Endocrinology, Elsevier Sci Ireland Ltd
  • Tacon LJ; Prichard RS; Soon PSH; Robinson B; Clifton-bligh RJ; Sidhu SB 2011, Current and emerging therapies for advanced adrenocortical carcinoma, Oncologist, Alphamed Press
  • Sidhu SB; Soon PSH 2010, Adrenocortical carcinoma, Cancer Treatment and Research
  • Tacon LJ; Soon PS; Gill AJ; Chou AS; Clarkson A; Botling J; Stalberg PL; Skogseid BM; Robinson BG; Sidhu SB 2010, The glucocorticoid receptor is overexpressed in malignant adrenocortical tumors, Journal of Urology
  • Soon PSH; Tacon LJ; Clifton-Bligh RJ; Robinson BG; Sidhu SB; Campbell PR; Gill AJ; Bambach CP; Sywak MS; Yeh MW 2010, MicroRNA microarray analysis of human adrenocortical tumors identifies miR-195 and miR-483-5p as predictors of poor prognosis in adrenocortical cancer - Response, Clinical Cancer Research
  • O''neill C; Spence A; Logan B; Suliburk J 2010, Adrenal Incidentalomas: Risk of Adrenocortical Carcinoma and Clinical Outcomes, Journal of Surgical Oncology, Wiley-Liss

E1 - Conference Abstract

  • Soon PS, Kim E, Benn DE, Baxter R 2015, Chemokines released by breast cancer-associated fibroblasts induce epithelial to mesenchymal transition in MCF7 breast cancer cells, 37th Annual CTRC-AACR San Antonio Breast Cancer Symposium, AMER ASSOC CANCER RESEARCH, vol. 75, no. 9
  • Lim C, Akra R, Yarrow S, Segara D, Soon P 2015, Can the Content of Seroma Fluid from Mastectomy or Axillary Clearance Wounds Predict Clinical Course?, CHURCHILL LIVINGSTONE, vol. 24, no. 3, pp. 302-303

Grants

  • 2014 The role of microRNAs in cancer-associated fibroblasts of triple negative breast cancers Soon, PS*; Cancer Australia.